Sharda Sinha Death: 'Bihar Kokila' died due to Septicemia; know if women are more prone to it

Sharda Sinha, also popularly known as 'Bihar Kokila', renowned for her songs in Bhojpuri, Maithili, and Hindi passed away at the age of 72 on Tuesday, due to blood poisoning complications. Just before the second day of 'Chhath' Puja, the legendary singer who sang the most famous songs of 'Chhathi Maiya' left the Bhojpuri industry in shock. Sinha was fighting multiple myeloma which is a type of blood cancer. She had been placed on the ventilator a week before her death, following which her condition got serious. On Monday, her condition deteriorated, and the following day she passed away at the All India Institute of Medical Sciences (AIIMS) in Delhi.?

Sharda Sinha was diagnosed with Blood Cancer in 2018?

The 'Bihar Kokila' was battling multiple myeloma which is a type of blood cancer and she was detected with the condition in 2018. What is multiple Myeloma and who are at risk of this deadly disease??

According to?Dr Niti Raizada, Senior Director - Medical Oncology & Hemato-Oncology, Fortis Hospitals, Bengaluru,?multiple myeloma is a type of blood cancer that affects plasma cells in the bone marrow. “Plasma cells produce antibodies to fight infections, but in myeloma, cancerous plasma cells accumulate, leading to bone damage, anaemia, and impaired immune function causing unusual infections ( when the disease is not in control),” she explains.?

Are you at risk of myeloma??

People at risk of developing myeloma often are from older age groups occasionally with a family history of myeloma, previous radiation exposure, and certain occupational exposures (for example; asbestos, pesticides etc). Additionally, certain viral infections like human herpesvirus 8 may increase the risk.?

According to Dr Raizada, “The exact cause of myeloma is unknown, but factors contributing to its development include genetic mutations, environmental exposures (radiation, chemicals), and viral infections. Underlying MGUS ( Monoclonal Gammapathy of Unknown Significance) also increases risk.” Lifestyle factors, such as obesity and smoking, may increase risk, but there is no direct link. Research suggests a possible link to diet, physical activity, and certain medications.?

Are women more vulnerable??

Dr Raizada elaborates, “Women are less vulnerable to myeloma than men. However, research suggests that women with myeloma tend to have poorer outcomes and shorter survival rates compared to men.”?

She goes on to explain that hormonal factors, differences in genetic expression, and healthcare access disparities may contribute to the thought that women have had poorer outcomes.?“Newer therapies like CAR-T cell therapy and traditional ones like Autologous Stem Cell Transplantation are often discussed and incorporated into therapy based on age and fitness,” she adds.?

Sharda Sinha's death was due to refractory shock and 'septicaemia'?

Septicemia, commonly known as blood poisoning, is an infection that occurs when germs get into the bloodstream and spread, according to?Cleveland Clinic. The germs are generally bacteria but they can also be viruses or fungi. Septicemia can lead to sepsis which can be a life-threatening medical emergency and can cause tissue damage, organ failure or even death.?

“Refractory shock and septicemia can occur in advanced myeloma due to compromised immune function. Infections, such as pneumonia or urinary tract infections, can lead to sepsis. Sepsis can subsequently cause refractory shock, renal dysfunction, other organ failure, and death. Early detection and treatment of infections are crucial in myeloma patients,” added Dr Raizada.?